DNA nanotechnology—the research field using DNA
molecules as building material—has developed rapidly during recent
years and enabled the construction of increasingly complex
nanostructures. DNA nanostructures, such as DNA origami, serve as
an excellent foundation for nanocarrier-based drug delivery
applications, and examples of their use in medical treatments have
already been demonstrated. Although the stability of such DNA
nanostructures under physiological conditions can be improved,
little is known about their digestion by endonucleases, which,
found everywhere in our blood and tissues, are responsible for
destroying foreign DNA in our bodies.