Nanoparticles used in drug delivery systems,
bioimaging, and regenerative medicine migrate from tissues to
lymphatic vessels after entering the body, so it is necessary to
clarify the interaction between nanoparticles and lymphatic
vessels. Although technology to observe the flow of nanoparticles
through lymphatic vessels in vivo has been developed, there has
been no method to evaluate the flow of nanoparticles in a more
detailed and quantitative manner ex vivo. Thus, research was
conducted to develop an ex vivo lymphatic vessel lumen perfusion
system to determine how nanoparticles move in lymphatic vessels and
how they affect the physiological movement of lymphatic
vessels.
Dynamics of nanoparticles using a new isolated lymphatic
vessel lumen perfusion system
