Lanthanide-doped nanoparticles (LnNPs) can harvest the
near-infrared (NIR) light to emit higher energy photons
(upconversion) or lower energy photons (downshifting). In a recent
study published in ACS Nano, a team led by Prof. CHANG Yulei from
Changchun Institute of Optics, Fine Mechanics and Physics of the
Chinese Academy of Sciences developed a novel photoswitchable
nanoparticle based on LnNPs for antitumor application, which had
UV-blue and NIR-IIb (1525 nm) emission upon 980 nm laser, and 1525
nm emission upon 800 nm laser. The above nanoparticles were further
used for achieving real-time NIR-IIb (800 nm) imaging-guided
photodynamic therapy (PDT) (980 nm).
Precise antitumor strategy achieved via photo-switchable
lanthanide-doped nanoparticles
