Johns Hopkins Medicine researchers have developed a
color-coded test that quickly signals whether newly developed
nanoparticles—ultra small compartments designed to ferry medicines,
vaccines and other therapies—deliver their cargo into target cells.
Historically, nanoparticles have a very low delivery rate to the
cytosol, the inside compartment of cells, releasing only about
1%–2% of their contents. The new testing tool, engineered
specifically to test nanoparticles, could advance the search for
next-generation biological medicines. The technology builds upon
nanoparticles currently used against cancer and eye disease, and in
vaccines for viruses including SARS-CoV-2, the virus that causes
COVID-19.
New color-coded test quickly reveals whether medical
nanoparticles have successfully delivered their payload
