Light-controlled ‘drug-free’ macromolecules for precise
tumor therapy

Drug-free macromolecular therapies can induce cell
apoptosis by clustering non-internalizing cell-surface receptors.
These show enormous promise in tumor treatment, particularly in
terms of non-specific toxicities when compared with
low-molecular-weight drugs. However, most reported drug-free
macromolecular therapies involve a ‘two-step’ administration manner
and there is a paucity of in vivo research.