Developing an efficient delivery system for enhanced
and controlled gene interference-based therapeutics is an existing
challenge in molecular biology. The advancing field of
nanotechnology can provide an effective, cross-disciplinary
strategy to facilitate nucleic acid delivery. In a new report,
Shuaidong Huo and colleagues in the interdisciplinary departments
of Nanoscience, Interactive Materials, Chemistry and Polymer
Research in China, Germany and the U.S. used triplex-forming
oligonucleotide sequences coupled to its complementary strand to
mediate the self-assembly of ultra-small gold
nanoparticles.
Gold-DNA nanosunflowers for efficient gene silencing and
controlled transformation
