NewsEpirubicin-loaded nanomedicines beat immune checkpoint
blockade resistance in glioblastoma

7th August 2020by admin0
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A nanomedicine-based strategy for chemo-immunotherapy
(CIT) of glioblastoma (GBM), which has the worst prognosis among
brain tumors, was successfully developed. In vivo experiments
demonstrated that the combined use of epirubicin-encapsulating
nano-micelles (Epi/m) with immune checkpoint inhibitors (ICI)
eradicated PTEN-negative GBM, which is highly resistant to ICI
alone. Due to the synergistic effects of Epi/m plus ICI
combination, the number of tumor-infiltrating T cells (TIL) and
other antitumor immune cells significantly increased to kill cancer
cells effectively.

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      The New Fusion technology is based on a phenomenon called triplet-triplet annihilation (TTA) which is a process in which two triplet excitons annihilate and produce a higher energy singlet exciton.

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