Bioresponsive micro-to-nano albumin-based systems for
targeted drug delivery against complex fungal infections

As a typical human pathogenic fungus, Cryptococcus
neoformansis a life-threatening invasive fungal pathogen with a
worldwide distribution causing ∼700,000 deaths annually.
Cryptococcosis is not just an infection with multi-organ
involvement, intracellular survival and extracellular
multiplication of the fungus also play important roles in the
pathogenesis of C. neoformansinfections. Because adequate
accumulation of drugs at target organs and cells is still difficult
to achieve, an effective delivery strategy is desperately required
to treat these infections.